This research program focuses on molecular causes and pathogenic mechanisms of broad spectrum of human diseases. Research teams which participate in this project use experimental models including bacteria, invertebrates, tissue cultures, experimental animals and patient samples to investigate etiology and pathogenesis of diseases on molecular, cellular and tissue level. The advanced molecular and cell biology methods are used to explore etiology and pathogenesis of diseases on genomic, proteomic and metabolomic level. New animal models and bioinformatic tools are being developed in the program.

The main research topics include:

• Identification of genetic causes of inherited diseases
• Study of molecular processes involved in physiology and patholophysiology
• Studies on interaction of the host and microorganisms and pathogenesis of bacterial, viral, protozoan and prion diseases

 

Research teams from following institutes and departments of the First Faculty of Medicine participate in the project:

• Ústav patologické fyziologie | Institute of Pathological Physiology
• Klinika dětského a dorostového lékařství | Department of Pediatrics and Adolescent Medicine
• Ústav lékařské biochemie a laboratorní diagnostiky | Institute of Medical Biochemistry and Laboratory Diagnostics
• Ústav imunologie a mikrobiologie | Institute of Immunology and Microbiology
• Klinika infekčních nemocí | Department of Infectious Diseases
• Ústav humanitních studií v lékařství | Institute for medical humanities
• BIOCEV 
• Pneumologická klinika | Department of Pneumology

Project coordinator: Doc. MUDr. Martin Vokurka, CSc (email)