The main goal of this research program is to analyze pathogenic mechanisms and identify new biomarkers which may be present in development of the complications of metabolic diseases, especially of diabetes mellitus, obesity, dyslipoproteinemias, kidney diseases, gastrointestinal tract diseases and rheumatic diseases including osteopathies. It includes also the interactions between disorders at molecular, cellular and organ levels.

The whole program involves four research pillars (one experimental and three clinical): (1) The key pathogenic mechanisms of the complication development, (2) The relationship of metabolic and endocrine disorders to vascular pathology, (3) Kidney and rheumatic disorders and their relationship to systemic as well as connective tissue impairments, (4) Interaction of individuals with the environment when metabolic disease has been already present.

Following theoretical and clinical departments of the First Faculty of Medicine participate in the project:

• Ústav pro histologii a embryologii | Institute of Histology and Embryology
• Fyziologický ústav | Institute of Physiology
• Ústav biologie a lékařské genetiky | Institute of Biology and Medical Genetics
• Farmakologický ústav | Institute of Pharmacology
• Ústav hygieny a epidemiologie | Institute of Hygiene and Epidemiology
• Centrum pro experimentální biomodely | The Center for experimental biomodels
• Ústav imunologie a mikrobiologie | Institute of Immunology and Microbiology
• Ústav lékařské biochemie a laboratorní diagnostiky | Institute of Medical Biochemistry and Laboratory Diagnostics
• Klinika nefrologie | Department of Nephrology
• III. interní klinika | 3^rd Medical Department
• IV.interní klinika | 4^th Department of Internal Medicine
• Klinika pracovního lékařství | Department of Occupational Medicine
• Geriatrická klinika 1. LF | Department of Geriatrics
• Revmatologická klinika | 
• I. chirurgická klinika | 1^st Surgical Department
• III. chirurgická klinika a FN Motol | 3^rd Department of Surgery
• Ortopedická klinika a FN Motol | 1st Department of Orthopaedics
• Oční klinika | Department of Ophthalmology
• Neurochirurgická klinika |

 

Project coordinator: prof. MUDr. Jan Škrha, DrSc.