The main goal of this research program is to analyze pathogenic mechanisms and identify new biomarkers which may be present in development of the complications of metabolic diseases, especially of diabetes mellitus, obesity, dyslipoproteinemias, kidney diseases, gastrointestinal tract diseases and rheumatic diseases including osteopathies. It includes also the interactions between disorders at molecular, cellular and organ levels.
The analysis of biomarkers will enable to evaluate both risks in developments of complications as direct consequences of metabolic disorders and their contribution in early diagnosis and sufficient treatment. It may be perspectively used for recommendations in the prevention of complications. The whole program involves four research pillars (one experimental and three clinical):
- The key pathogenic mechanisms of the complication development
- The relationship of metabolic and endocrine disorders to vascular pathology
- Kidney and rheumatic disorders and their relationship to systemic as well as connective tissue impairments
- Interaction of individuals with the environment when metabolic disease has been already present